Home › Cruises › From Colon, Panama Cruises from Colon, Panama 3 cruise routes departing from Colon, Panama. All Sailings Colon, Panama to Colon, Panama 7 nights on Serenade of the Seas by Royal Caribbean International — 2026-04-11 Colon, Panama to Los Angeles, California 10 nights on Serenade of the Seas by Royal Caribbean International — 2026-04-25 Colon, Panama to Cartagena, Colombia 1 nights on Serenade of the Seas by Royal Caribbean International — 2026-04-18